Development of Therapeutic Chimeric Uricase by Exon Replacement/Restoration and Site-Directed Mutagenesis

The activity of urate oxidase was lost during hominoid evolution, resulting in high susceptibility to hyperuricemia and gout in humans. In order to develop a more “human-like” uricase for therapeutic use, exon replacement/restoration and site-directed mutagenesis were performed to obtain porcine–hum...

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Detalles Bibliográficos
Autores principales: Xie, Guangrong, Yang, Weizhen, Chen, Jing, Li, Miaomiao, Jiang, Nan, Zhao, Baixue, Chen, Si, Wang, Min, Chen, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881585/
https://www.ncbi.nlm.nih.gov/pubmed/27213357
http://dx.doi.org/10.3390/ijms17050764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881585/
https://www.ncbi.nlm.nih.gov/pubmed/27213357
http://dx.doi.org/10.3390/ijms17050764

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