Cargando…

Downregulation of Runx2 by 1,25-Dihydroxyvitamin D(3) Induces the Transdifferentiation of Osteoblasts to Adipocytes

1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) indirectly stimulates bone formation, but little is known about its direct effect on bone formation. In this study, we observed that 1,25(OH)(2)D(3) enhances adipocyte differentiation, but inhibits osteoblast differentiation during osteogenesis. The posit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Jung Ha, Seong, Semun, Kim, Kabsun, Kim, Inyoung, Jeong, Byung-Chul, Kim, Nacksung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881589/ https://www.ncbi.nlm.nih.gov/pubmed/27213351 http://dx.doi.org/10.3390/ijms17050770

Ejemplares similares

The ATF3–OPG Axis Contributes to Bone Formation by Regulating the Differentiation of Osteoclasts, Osteoblasts, and Adipocytes
por: Kim, Jung Ha, et al.
Publicado: (2022)

The IRF2BP2-KLF2 axis regulates osteoclast and osteoblast differentiation
por: Kim, Inyoung, et al.
Publicado: (2019)

Rev-erbα Negatively Regulates Osteoclast and Osteoblast Differentiation through p38 MAPK Signaling Pathway
por: Kim, Kabsun, et al.
Publicado: (2020)

Overexpression of Neurogenin 1 Negatively Regulates Osteoclast and Osteoblast Differentiation
por: Kim, Jung Ha, et al.
Publicado: (2022)

Alternative regulatory mechanism for the maintenance of bone homeostasis via STAT5-mediated regulation of the differentiation of BMSCs into adipocytes
por: Seong, Semun, et al.
Publicado: (2021)

Adaptor protein CrkII negatively regulates osteoblast differentiation and function through JNK phosphorylation
por: Kim, Jung Ha, et al.
Publicado: (2019)

GATA4 negatively regulates osteoblast differentiation by downregulation of Runx2
por: Song, Insun, et al.
Publicado: (2014)

NRROS Negatively Regulates Osteoclast Differentiation by Inhibiting RANKL-Mediated NF-κB and Reactive Oxygen Species Pathways
por: Kim, Jung Ha, et al.
Publicado: (2015)

Tusc2/Fus1 regulates osteoclast differentiation through NF-κB and NFATc1
por: Kim, Inyoung, et al.
Publicado: (2017)

Transcription Factor Lmx1b Negatively Regulates Osteoblast Differentiation and Bone Formation
por: Kim, Kabsun, et al.
Publicado: (2022)

IRF2 enhances RANKL-induced osteoclast differentiation via regulating NF-κB/NFATc1 signaling
por: Kim, Inyoung, et al.
Publicado: (2021)

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation
por: Kim, Kabsun, et al.
Publicado: (2015)

RCANs regulate the convergent roles of NFATc1 in bone homeostasis
por: Kim, Jung Ha, et al.
Publicado: (2016)

STAT5 is a key transcription factor for IL-3-mediated inhibition of RANKL-induced osteoclastogenesis
por: Lee, Jongwon, et al.
Publicado: (2016)

Bifunctional Role of CrkL during Bone Remodeling
por: Kim, Jung Ha, et al.
Publicado: (2021)

Effects of 1,25-dihydroxyvitamin D(3) on the differentiation of MC3T3-E1 osteoblast-like cells
por: Kim, Hyun-Soo, et al.
Publicado: (2018)

Kruppel-like factor 4 attenuates osteoblast formation, function, and cross talk with osteoclasts
por: Kim, Jung Ha, et al.
Publicado: (2014)

Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts
por: Qin, Xin, et al.
Publicado: (2020)

Primary Human Osteoblasts in Response to 25-Hydroxyvitamin D(3), 1,25-Dihydroxyvitamin D(3) and 24R,25-Dihydroxyvitamin D(3)
por: van der Meijden, Karen, et al.
Publicado: (2014)

Effects of 1,25-Dihydroxyvitamin D3 on the Inflammatory Responses of Stromal Vascular Cells and Adipocytes from Lean and Obese Mice
por: Park, Chan Yoon, et al.
Publicado: (2020)

1,25-dihydroxyvitamin D deficiency is independently associated with cardiac valve calcification in patients with chronic kidney disease
por: Kim, Il Young, et al.
Publicado: (2022)

Dexamethasone and 1,25-Dihydroxyvitamin D3 Reduce Oxidative Stress-Related DNA Damage in Differentiating Osteoblasts
por: Pawlowska, Elzbieta, et al.
Publicado: (2014)

THU233 Reduction Of Overutilization Of 1,25-Dihydroxyvitamin D
por: Brown, Jeremy, et al.
Publicado: (2023)

1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice
por: Chen, Jie, et al.
Publicado: (2023)

MON-374 Management of 1,25-dihydroxyvitamin D (1,25-OHD) Mediated Hypercalcemia of Unknown Etiology
por: Menon, Sruthi, et al.
Publicado: (2020)

Serum 1,25-Dihydroxyvitamin D: An Outcome Prognosticator in Human Sepsis
por: Nguyen, H. Bryant, et al.
Publicado: (2013)

Focus on 1,25-Dihydroxyvitamin D3 in the Peripheral Nervous System
por: Faye, Pierre Antoine, et al.
Publicado: (2019)

Role of 1,25-Dihydroxyvitamin D(3) on Osteogenic Differentiation and Mineralization of Chicken Mesenchymal Stem Cells
por: Chen, Chongxiao, et al.
Publicado: (2021)

Hypercalcemia of Malignancy: Simultaneous Elevation in Parathyroid Hormone-Related Peptide and 1,25 Dihydroxyvitamin D in Sarcoma
por: Kim, Dong Won, et al.
Publicado: (2021)

Serum 1,25-dihydroxyvitamin D Better Reflects Renal Parameters Than 25-hydoxyvitamin D in Patients with Glomerular Diseases
por: Chung, Sungjin, et al.
Publicado: (2017)

Adipocyte-induced transdifferentiation of osteoblasts and its potential role in age-related bone loss
por: Clabaut, Aline, et al.
Publicado: (2021)

Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3
por: Halicka, H. Dorota, et al.
Publicado: (2012)

The relationship of 1,25-dihydroxyvitamin D and Vitamin D binding protein in periodontitis
por: Rafique, Sara, et al.
Publicado: (2019)

Mechanistic study of the cause of decreased blood 1,25-Dihydroxyvitamin D in sepsis
por: Li, Chih-Huang, et al.
Publicado: (2019)

The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts
por: Lisse, Thomas S, et al.
Publicado: (2014)

CCAAT/enhancer-binding protein beta (C/EBPβ) is an important mediator of 1,25 dihydroxyvitamin D3 (1,25D3)-induced receptor activator of nuclear factor kappa-B ligand (RANKL) expression in osteoblasts
por: Jo, Sungsin, et al.
Publicado: (2019)

8-Cl-Adenosine enhances 1,25-dihydroxyvitamin D(3)-induced growth inhibition without affecting 1,25-dihydroxyvitamin D(3)-stimulated differentiation of primary mouse epidermal keratinocytes
por: Bollag, Wendy B, et al.
Publicado: (2004)

25-Hydroxyvitamin D, 1,25-Dihydroxyvitamin D, and Peripheral Bone Densitometry in Adults with Celiac Disease
por: Ciacci, Carolina, et al.
Publicado: (2020)

Characteristics of Serum Ratios of 1,25-Dihydroxyvitamin D to 25-Hydroxyvitamin D for Assessment of Bone Metabolism
por: Yamamoto, Koichiro, et al.
Publicado: (2021)

Responses of primary osteoblasts and osteoclasts from hemizygous β-globin knockout thalassemic mice with elevated plasma glucose to 1,25-dihydroxyvitamin D(3)
por: Charoenphandhu, Narattaphol, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_qqe1022m67itbjdccgfccr64sm