CD14 Is a Co-Receptor for TLR4 in the S100A9-Induced Pro-Inflammatory Response in Monocytes

The cytosolic Ca(2+)-binding S100A9 and S100A8 proteins form heterodimers that are primarily expressed in human neutrophils and monocytes. We have recently shown that S100A9 binds to TLR4 in vitro and induces TLR4-dependent NF-κB activation and a pro-inflammatory cytokine response in monocytes. In t...

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Detalles Bibliográficos
Autores principales: He, Zhifei, Riva, Matteo, Björk, Per, Swärd, Karl, Mörgelin, Matthias, Leanderson, Tomas, Ivars, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881898/
https://www.ncbi.nlm.nih.gov/pubmed/27228163
http://dx.doi.org/10.1371/journal.pone.0156377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881898/
https://www.ncbi.nlm.nih.gov/pubmed/27228163
http://dx.doi.org/10.1371/journal.pone.0156377

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