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Predicting Ancestral Segmentation Phenotypes from Drosophila to Anopheles Using In Silico Evolution

Molecular evolution is an established technique for inferring gene homology but regulatory DNA turns over so rapidly that inference of ancestral networks is often impossible. In silico evolution is used to compute the most parsimonious path in regulatory space for anterior-posterior patterning linki...

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Detalles Bibliográficos
Autores principales: Rothschild, Jeremy B., Tsimiklis, Panagiotis, Siggia, Eric D., François, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882032/
https://www.ncbi.nlm.nih.gov/pubmed/27227405
http://dx.doi.org/10.1371/journal.pgen.1006052