Exploring the Origin of Differential Binding Affinities of Human Tubulin Isotypes αβII, αβIII and αβIV for DAMA-Colchicine Using Homology Modelling, Molecular Docking and Molecular Dynamics Simulations

Tubulin isotypes are found to play an important role in regulating microtubule dynamics. The isotype composition is also thought to contribute in the development of drug resistance as tubulin isotypes show differential binding affinities for various anti-cancer agents. Tubulin isotypes αβ(II), αβ(II...

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Detalles Bibliográficos
Autores principales: Kumbhar, Bajarang Vasant, Borogaon, Anubhaw, Panda, Dulal, Kunwar, Ambarish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882049/
https://www.ncbi.nlm.nih.gov/pubmed/27227832
http://dx.doi.org/10.1371/journal.pone.0156048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882049/
https://www.ncbi.nlm.nih.gov/pubmed/27227832
http://dx.doi.org/10.1371/journal.pone.0156048

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