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BANK1 Regulates IgG Production in a Lupus Model by Controlling TLR7-Dependent STAT1 Activation

The purpose of our study was to investigate the effects of the adaptor Bank1 in TLR7 signaling using the B6.Sle1.yaa mouse, a lupus model that develops disease through exacerbated TLR7 expression. Crosses of B6.Sle1.yaa with Bank1(-/-) mice maintained several B and myeloid cell phenotypes close to n...

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Detalles Bibliográficos
Autores principales: Wu, Ying-Yu, Kumar, Ramesh, Iida, Ryuji, Bagavant, Harini, Alarcón-Riquelme, Marta E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882053/
https://www.ncbi.nlm.nih.gov/pubmed/27228057
http://dx.doi.org/10.1371/journal.pone.0156302