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BANK1 Regulates IgG Production in a Lupus Model by Controlling TLR7-Dependent STAT1 Activation
The purpose of our study was to investigate the effects of the adaptor Bank1 in TLR7 signaling using the B6.Sle1.yaa mouse, a lupus model that develops disease through exacerbated TLR7 expression. Crosses of B6.Sle1.yaa with Bank1(-/-) mice maintained several B and myeloid cell phenotypes close to n...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882053/ https://www.ncbi.nlm.nih.gov/pubmed/27228057 http://dx.doi.org/10.1371/journal.pone.0156302 |