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Suppression of USP18 Potentiates the Anti-HBV Activity of Interferon Alpha in HepG2.2.15 Cells via JAK/STAT Signaling

Ubiquitin-specific protease 18 (USP18, also known as UBP43) has both interferon stimulated gene 15 (ISG15) dependent and ISG15-independent functions. By silencing the expression of USP18 in HepG2.2.15 cells, we studied the effect of USP18 on the anti-HBV activity of IFN-α and demonstrated that knock...

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Detalles Bibliográficos
Autores principales: Li, Lin, Lei, Qing-song, Zhang, Shu-Jun, Kong, Ling-na, Qin, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882066/
https://www.ncbi.nlm.nih.gov/pubmed/27227879
http://dx.doi.org/10.1371/journal.pone.0156496