Phase 1 study of cardiac safety of TAS-102 in patients with advanced solid tumors

PURPOSE: TAS-102 is a novel oral agent combining the antineoplastic thymidine-based nucleoside analogue, trifluridine, and the thymidine phosphorylase inhibitor, tipiracil (molar ratio 1:0.5). TAS-102 has shown good activity in refractory metastatic colorectal cancer with acceptable safety. No QT pr...

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Detalles Bibliográficos
Autores principales: Bendell, Johanna C., Patel, Manish R., Yoshida, Kenichiro, Seraj, Jabed, Weaver, Racquel, Lemech, Charlotte, Todaro, Thomas G., Pant, Shubham, Arkenau, Hendrik-Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882359/
https://www.ncbi.nlm.nih.gov/pubmed/27151157
http://dx.doi.org/10.1007/s00280-016-3031-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882359/
https://www.ncbi.nlm.nih.gov/pubmed/27151157
http://dx.doi.org/10.1007/s00280-016-3031-9

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