Cargando…

Exploring the Inhibitory Mechanism of Approved Selective Norepinephrine Reuptake Inhibitors and Reboxetine Enantiomers by Molecular Dynamics Study

Selective norepinephrine reuptake inhibitors (sNRIs) provide an effective class of approved antipsychotics, whose inhibitory mechanism could facilitate the discovery of privileged scaffolds with enhanced drug efficacy. However, the crystal structure of human norepinephrine transporter (hNET) has not...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Guoxun, Xue, Weiwei, Wang, Panpan, Yang, Fengyuan, Li, Bo, Li, Xiaofeng, Li, Yinghong, Yao, Xiaojun, Zhu, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882549/ https://www.ncbi.nlm.nih.gov/pubmed/27230580 http://dx.doi.org/10.1038/srep26883

Ejemplares similares

The selective norepinephrine reuptake inhibitor reboxetine promotes late-stage fracture healing in mice
por: Donat, Antonia, et al.
Publicado: (2023)

Alpha adrenergic modulation on effects of norepinephrine transporter inhibitor reboxetine in five-choice serial reaction time task
por: Liu, Yia-Ping, et al.
Publicado: (2009)

Sentiment Analysis of Online Reviews for Selective Serotonin Reuptake Inhibitors and Serotonin–Norepinephrine Reuptake Inhibitors
por: Compagner, Chad, et al.
Publicado: (2021)

Reboxetine Improves Auditory Attention and Increases Norepinephrine Levels in the Auditory Cortex of Chronically Stressed Rats
por: Pérez-Valenzuela, Catherine, et al.
Publicado: (2016)

Improvement of social adaptation in depression with serotonin and norepinephrine reuptake inhibitors
por: Briley, Mike, et al.
Publicado: (2010)

Serotonin-Norepinephrine Reuptake Inhibitors for Pain Control: Premise and Promise
por: Marks, David M, et al.
Publicado: (2009)

Selective Serotonin–norepinephrine Reuptake Inhibitors-induced Takotsubo Cardiomyopathy
por: Vasudev, Rahul, et al.
Publicado: (2016)

New Serotonin-Norepinephrine Reuptake Inhibitors and Their Anesthetic and Analgesic Considerations
por: Fanelli, David, et al.
Publicado: (2021)

Structural Requirements for Modulating 4-Benzylpiperidine Carboxamides from Serotonin/Norepinephrine Reuptake Inhibitors to Triple Reuptake Inhibitors
por: Paudel, Suresh, et al.
Publicado: (2021)

Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and selective serotonin reuptake inhibitor controlled trials
por: Eyding, Dirk, et al.
Publicado: (2010)

Japanese experience with milnacipran, the first serotonin and norepinephrine reuptake inhibitor in Japan
por: Higuchi, Teruhiko, et al.
Publicado: (2007)

Serotonin-norepinephrine reuptake inhibitors may exacerbate stiff-person syndrome
Publicado: (2016)

Serotonin-norepinephrine reuptake inhibitors may exacerbate stiff-person syndrome
por: Benavides, David R., et al.
Publicado: (2016)

Design and Synthesis of Arylamidine Derivatives as Serotonin/Norepinephrine Dual Reuptake Inhibitors
por: Wen, Hui, et al.
Publicado: (2019)

Reboxetine-induced urinary hesitancy
por: Borade, Suresh, et al.
Publicado: (2005)

Chiral Resolution of the Enantiomers of the Slow-Onset Dopamine Reuptake Inhibitor CTDP-32476 and Their Activities
por: Froimowitz, Mark, et al.
Publicado: (2023)

Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
por: Qin, Xuan, et al.
Publicado: (2022)

Effects of Norepinephrine Reuptake Inhibition on Postural Tachycardia Syndrome
por: Green, Elizabeth A., et al.
Publicado: (2013)

Norepinephrine reuptake blockade to treat neurogenic orthostatic hypotension
por: Eisenhofer, Graeme, et al.
Publicado: (2021)

Modulation of muscarinic system with serotonin-norepinephrine reuptake inhibitor antidepressant attenuates depression in mice
por: Singh, Paramdeep, et al.
Publicado: (2015)

Delayed Presentation of Posterior Reversible Encephalopathy Syndrome in the Setting of Serotonin-Norepinephrine Reuptake Inhibitors
por: Bhutada, Abhishek S, et al.
Publicado: (2022)

Chronic SSRI Treatment, but Not Norepinephrine Reuptake Inhibitor Treatment, Increases Neurogenesis in Juvenile Rats
por: Hovorka, Michelle, et al.
Publicado: (2022)

Selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors for anxiety, obsessive-compulsive, and stress disorders: A 3-level network meta-analysis
por: Gosmann, Natan Pereira, et al.
Publicado: (2021)

The Efficacy and Safety of Selective Serotonin Reuptake Inhibitors and Serotonin-Norepinephrine Reuptake Inhibitors in the Treatment of Menopausal Hot Flashes: A Systematic Review of Clinical Trials
por: Azizi, Marzieh, et al.
Publicado: (2022)

Clinical Utility of Semistructured Interview and Scales to Assess Withdrawal Syndromes With Dose Reduction or Discontinuation of Selective Serotonin Reuptake Inhibitors or Serotonin Norepinephrine Reuptake Inhibitors
por: Cosci, Fiammetta, et al.
Publicado: (2022)

The Effects of LPM570065, a Novel Triple Reuptake Inhibitor, on Extracellular Serotonin, Dopamine and Norepinephrine Levels in Rats
por: Zhang, Renyu, et al.
Publicado: (2014)

The effect of hepatic or renal impairment on the pharmacokinetics of edivoxetine, a selective norepinephrine transporter reuptake inhibitor
por: Kielbasa, William, et al.
Publicado: (2013)

Onset of Transient Sadness Following the Concomitant Use of a Triptan and Selective Serotonin Reuptake Inhibitor/Serotonin Norepinephrine Reuptake Inhibitors Therapy: A Case Report
por: Meng, Yuki, et al.
Publicado: (2021)

Disposition and metabolism of [(14)C]-levomilnacipran, a serotonin and norepinephrine reuptake inhibitor, in humans, monkeys, and rats
por: Brunner, Valérie, et al.
Publicado: (2015)

Pharmacokinetics and pharmacodynamics of ampreloxetine, a novel, selective norepinephrine reuptake inhibitor, in symptomatic neurogenic orthostatic hypotension
por: Lo, Arthur, et al.
Publicado: (2021)

Mixed lymphocytic and collagenous inflammation of the entire gastrointestinal tract under therapy with serotonin and norepinephrine reuptake inhibitors
por: Varelas, Ana I., et al.
Publicado: (2022)

Fatigue-related impairments in oculomotor control are prevented by norepinephrine-dopamine reuptake inhibition
por: Connell, Charlotte J. W., et al.
Publicado: (2017)

Pharmacometric Analyses to Support Early Development Decisions for LY2878735: A Novel Serotonin Norepinephrine Reuptake Inhibitor
por: Raddad, E, et al.
Publicado: (2013)

Preclinical to Clinical Translation of CNS Transporter Occupancy of TD-9855, a Novel Norepinephrine and Serotonin Reuptake Inhibitor
por: Smith, Jacqueline AM, et al.
Publicado: (2015)

Cognitive Deficits Following a Post-Myocardial Infarct in the Rat Are Blocked by the Serotonin-Norepinephrine Reuptake Inhibitor Desvenlafaxine
por: Malick, Mandy, et al.
Publicado: (2018)

Effect of serotonin-norepinephrine reuptake inhibitors for patients with chemotherapy-induced painful peripheral neuropathy: A meta-analysis
por: Song, Soo Youn, et al.
Publicado: (2020)

Comparison of adjunctive use of aripiprazole with bupropion or selective serotonin reuptake inhibitors/serotonin–norepinephrine reuptake inhibitors: analysis of patients beginning adjunctive treatment in a 52-week, open-label study
por: Clayton, Anita H, et al.
Publicado: (2014)

Unravelling Impaired Hypoalgesia at Rest and in Response to Exercise in Patients with Chronic Whiplash-Associated Disorders: Effects of a Single Administration of Selective Serotonin Reuptake Inhibitor versus Selective Norepinephrine Reuptake Inhibitor
por: De Kooning, Margot, et al.
Publicado: (2023)

High-Fat Diet-Induced Alterations in the Feeding Suppression of Low-Dose Nisoxetine, a Selective Norepinephrine Reuptake Inhibitor
por: Bello, Nicholas T., et al.
Publicado: (2013)

Pharmacological and Behavioral Characterization of D-473, an Orally Active Triple Reuptake Inhibitor Targeting Dopamine, Serotonin and Norepinephrine Transporters
por: Dutta, Aloke K., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ho0m4q7r8d7d2ls7jduesjl835