Prolonged mitotic arrest induces a caspase-dependent DNA damage response at telomeres that determines cell survival

A delay in the completion of metaphase induces a stress response that inhibits further cell proliferation or induces apoptosis. This response is thought to protect against genomic instability and is important for the effects of anti-mitotic cancer drugs. Here, we show that mitotic arrest induces a c...

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Detalles Bibliográficos
Autores principales: Hain, Karolina O., Colin, Didier J., Rastogi, Shubhra, Allan, Lindsey A., Clarke, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882748/
https://www.ncbi.nlm.nih.gov/pubmed/27230693
http://dx.doi.org/10.1038/srep26766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882748/
https://www.ncbi.nlm.nih.gov/pubmed/27230693
http://dx.doi.org/10.1038/srep26766

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