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Prolonged mitotic arrest induces a caspase-dependent DNA damage response at telomeres that determines cell survival
A delay in the completion of metaphase induces a stress response that inhibits further cell proliferation or induces apoptosis. This response is thought to protect against genomic instability and is important for the effects of anti-mitotic cancer drugs. Here, we show that mitotic arrest induces a c...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882748/ https://www.ncbi.nlm.nih.gov/pubmed/27230693 http://dx.doi.org/10.1038/srep26766 |