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Subthreshold nitric oxide synthase inhibition improves synergistic effects of subthreshold MMP‐2/MLCK‐mediated cardiomyocyte protection from hypoxic injury

Injury of myocardium during ischaemia/reperfusion (I/R) is a complex and multifactorial process involving uncontrolled protein phosphorylation, nitration/nitrosylation by increased production of nitric oxide and accelerated contractile protein degradation by matrix metalloproteinase‐2 (MMP‐2). It ha...

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Detalles Bibliográficos
Autores principales: Bil‐Lula, Iwona, Lin, Han‐Bin, Biały, Dariusz, Wawrzyńska, Magdalena, Diebel, Lucas, Sawicka, Jolanta, Woźniak, Mieczyslaw, Sawicki, Grzegorz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882990/
https://www.ncbi.nlm.nih.gov/pubmed/26992120
http://dx.doi.org/10.1111/jcmm.12827