Histone H3.3 promotes IgV gene diversification by enhancing formation of AID‐accessible single‐stranded DNA

Immunoglobulin diversification is driven by activation‐induced deaminase (AID), which converts cytidine to uracil within the Ig variable (IgV) regions. Central to the recruitment of AID to the IgV genes are factors that regulate the generation of single‐stranded DNA (ssDNA), the enzymatic substrate...

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Detalles Bibliográficos
Autores principales: Romanello, Marina, Schiavone, Davide, Frey, Alexander, Sale, Julian E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883027/
https://www.ncbi.nlm.nih.gov/pubmed/27220848
http://dx.doi.org/10.15252/embj.201693958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883027/
https://www.ncbi.nlm.nih.gov/pubmed/27220848
http://dx.doi.org/10.15252/embj.201693958

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