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STIM1 activation is regulated by a 14 amino acid sequence adjacent to the CRAC activation domain
Oligomerization of the Ca(2+) sensor, STIM1, in the endoplasmic reticulum (ER) membrane, caused by depletion of ER Ca(2+) stores, results in STIM1 coupling to the plasma membrane Ca(2+) channel protein, Orai1, to activate Ca(2+) influx in a process known as store-operated Ca(2+) entry. We use fluori...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883682/ https://www.ncbi.nlm.nih.gov/pubmed/27239559 http://dx.doi.org/10.3934/biophy.2016.1.99 |