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Control of Ca(2+) Influx and Calmodulin Activation by SK-Channels in Dendritic Spines

The key trigger for Hebbian synaptic plasticity is influx of Ca(2+) into postsynaptic dendritic spines. The magnitude of [Ca(2+)] increase caused by NMDA-receptor (NMDAR) and voltage-gated Ca(2+) -channel (VGCC) activation is thought to determine both the amplitude and direction of synaptic plastici...

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Detalles Bibliográficos
Autores principales: Griffith, Thom, Tsaneva-Atanasova, Krasimira, Mellor, Jack R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883788/
https://www.ncbi.nlm.nih.gov/pubmed/27232631
http://dx.doi.org/10.1371/journal.pcbi.1004949