Ezetimibe-sensitive cholesterol uptake by NPC1L1 protein does not require endocytosis

Human NPC1L1 protein mediates cholesterol absorption in the intestine and liver and is the target of the drug ezetimibe, which is used to treat hypercholesterolemia. Previous studies concluded that NPC1L1-GFP protein trafficking is regulated by cholesterol binding and that ezetimibe blocks NPC1L1-GF...

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Detalles Bibliográficos
Autores principales: Johnson, Tory A., Pfeffer, Suzanne R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884074/
https://www.ncbi.nlm.nih.gov/pubmed/27075173
http://dx.doi.org/10.1091/mbc.E16-03-0154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884074/
https://www.ncbi.nlm.nih.gov/pubmed/27075173
http://dx.doi.org/10.1091/mbc.E16-03-0154

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