Attenuation of morphine tolerance and dependence by thymoquinone in mice

OBJECTIVE: Dependence and tolerance are major restricting factors in the clinical use of opioid analgesics. In the present study, the effects of thymoquinone, the major constituent of Nigella sativa seeds, on morphine dependence and tolerance were investigated in mice. MATERIALS AND METHODS: Male ad...

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Detalles Bibliográficos
Autores principales: Hosseinzadeh, Hossein, Parvardeh, Siavash, Masoudi, Alireza, Moghimi, Mahsa, Mahboobifard, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2016
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884218/
https://www.ncbi.nlm.nih.gov/pubmed/27247922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884218/
https://www.ncbi.nlm.nih.gov/pubmed/27247922

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