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T cell-derived interleukin-10 is an important regulator of the Th17 response during lethal alphavirus encephalomyelitis

Neuroadapted Sindbis virus infection of mice causes T cell-mediated fatal encephalomyelitis. In the absence of IL-10, pathogenic Th17 cells are increased and disease is accelerated. Lymphoid and myeloid cell contributions to IL-10 production were determined using VertX IL-10 transcriptional eGFP rep...

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Detalles Bibliográficos
Autores principales: Kulcsar, Kirsten A., Griffin, Diane E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884611/
https://www.ncbi.nlm.nih.gov/pubmed/27235350
http://dx.doi.org/10.1016/j.jneuroim.2016.04.010