SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development

Skp1‐Cul1‐F‐box protein (SCF) ubiquitin ligases direct cell survival decisions by controlling protein ubiquitylation and degradation. Sufu (Suppressor of fused) is a central regulator of Hh (Hedgehog) signaling and acts as a tumor suppressor by maintaining the Gli (Glioma‐associated oncogene homolog...

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Detalles Bibliográficos
Autores principales: Raducu, Madalina, Fung, Ella, Serres, Sébastien, Infante, Paola, Barberis, Alessandro, Fischer, Roman, Bristow, Claire, Thézénas, Marie‐Laëtitia, Finta, Csaba, Christianson, John C, Buffa, Francesca M, Kessler, Benedikt M, Sibson, Nicola R, Di Marcotullio, Lucia, Toftgård, Rune, D'Angiolella, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884786/
https://www.ncbi.nlm.nih.gov/pubmed/27234298
http://dx.doi.org/10.15252/embj.201593374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884786/
https://www.ncbi.nlm.nih.gov/pubmed/27234298
http://dx.doi.org/10.15252/embj.201593374

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