Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene

Human pluripotent stem cells (hPSCs) hold great promise for cell therapy. However, a major concern is the risk of tumor formation by residual undifferentiated cells contaminating the hPSC-derived cell product. Suicide genes could safeguard against such adverse events by enabling elimination of cells...

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Detalles Bibliográficos
Autores principales: Kotini, Andriana G, de Stanchina, Elisa, Themeli, Maria, Sadelain, Michel, Papapetrou, Eirini P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884789/
https://www.ncbi.nlm.nih.gov/pubmed/26836371
http://dx.doi.org/10.1038/mtna.2015.57

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884789/
https://www.ncbi.nlm.nih.gov/pubmed/26836371
http://dx.doi.org/10.1038/mtna.2015.57

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