Systematic drug perturbations on cancer cells reveal diverse exit paths from proliferative state

During a cell state transition, cells travel along trajectories in a gene expression state space. This dynamical systems framework complements the traditional concept of molecular pathways that drive cell phenotype switching. To expose the structure that hinders cancer cells from exiting robust prol...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Joseph X., Isik, Zerrin, Xiao, Caide, Rubin, Irit, Kauffman, Stuart A., Schroeder, Michael, Huang, Sui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884928/
https://www.ncbi.nlm.nih.gov/pubmed/26871731
http://dx.doi.org/10.18632/oncotarget.7294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884928/
https://www.ncbi.nlm.nih.gov/pubmed/26871731
http://dx.doi.org/10.18632/oncotarget.7294

Ejemplares similares