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Systematic drug perturbations on cancer cells reveal diverse exit paths from proliferative state
During a cell state transition, cells travel along trajectories in a gene expression state space. This dynamical systems framework complements the traditional concept of molecular pathways that drive cell phenotype switching. To expose the structure that hinders cancer cells from exiting robust prol...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884928/ https://www.ncbi.nlm.nih.gov/pubmed/26871731 http://dx.doi.org/10.18632/oncotarget.7294 |