Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin

Botulinum neurotoxins (BoNTs) exhibit extraordinary potency due to their exquisite neurospecificity, which is achieved by dual binding to complex polysialo-gangliosides and synaptic vesicle proteins. The luminal domain 4 (LD4) of the three synaptic vesicle glycoprotein 2 isoforms, SV2A‐C, identified...

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Detalles Bibliográficos
Autores principales: Weisemann, Jasmin, Stern, Daniel, Mahrhold, Stefan, Dorner, Brigitte G., Rummel, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885069/
https://www.ncbi.nlm.nih.gov/pubmed/27196927
http://dx.doi.org/10.3390/toxins8050154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885069/
https://www.ncbi.nlm.nih.gov/pubmed/27196927
http://dx.doi.org/10.3390/toxins8050154

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