STAT3 selectively interacts with Smad3 to antagonize TGF-β signaling

Smad and STAT proteins are critical signal transducers and transcription factors in controlling cell growth and tumorigenesis. Here we report that the STAT3 signaling pathway attenuates TGF-β-induced responses through a direct Smad3-STAT3 interplay. Activated STAT3 blunts TGF-β-mediated signaling. D...

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Detalles Bibliográficos
Autores principales: Wang, Gaohang, Yu, Yi, Sun, Chuang, Liu, Ting, Liang, Tingbo, Zhan, Lixing, Lin, Xia, Feng, Xin-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885808/
https://www.ncbi.nlm.nih.gov/pubmed/26616859
http://dx.doi.org/10.1038/onc.2015.446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885808/
https://www.ncbi.nlm.nih.gov/pubmed/26616859
http://dx.doi.org/10.1038/onc.2015.446

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