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STAT3 selectively interacts with Smad3 to antagonize TGF-β signaling

Smad and STAT proteins are critical signal transducers and transcription factors in controlling cell growth and tumorigenesis. Here we report that the STAT3 signaling pathway attenuates TGF-β-induced responses through a direct Smad3-STAT3 interplay. Activated STAT3 blunts TGF-β-mediated signaling. D...

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Detalles Bibliográficos
Autores principales:	Wang, Gaohang, Yu, Yi, Sun, Chuang, Liu, Ting, Liang, Tingbo, Zhan, Lixing, Lin, Xia, Feng, Xin-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885808/ https://www.ncbi.nlm.nih.gov/pubmed/26616859 http://dx.doi.org/10.1038/onc.2015.446

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