Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice

Insulin's stimulation of glucose uptake by binding to the IRK extracellular domain is compromised in diabetes. We have recently described an unprecedented approach to stimulating glucose uptake. KYCCSRK (P2) peptide, corresponding to the C-terminal segment of hBVR, was effective in binding to a...

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Detalles Bibliográficos
Autores principales: Gibbs, Peter E. M., Miralem, Tihomir, Lerner-Marmarosh, Nicole, Maines, Mahin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886063/
https://www.ncbi.nlm.nih.gov/pubmed/27294151
http://dx.doi.org/10.1155/2016/4712053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886063/
https://www.ncbi.nlm.nih.gov/pubmed/27294151
http://dx.doi.org/10.1155/2016/4712053

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