The exceptionally high reactivity of Cys 621 is critical for electrophilic activation of the sensory nerve ion channel TRPA1

Activation of the sensory nerve ion channel TRPA1 by electrophiles is the key mechanism that initiates nociceptive signaling, and leads to defensive reflexes and avoidance behaviors, during oxidative stress in mammals. TRPA1 is rapidly activated by subtoxic levels of electrophiles, but it is unclear...

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Detalles Bibliográficos
Autores principales: Bahia, Parmvir K., Parks, Thomas A., Stanford, Katherine R., Mitchell, David A., Varma, Sameer, Stevens, Stanley M., Taylor-Clark, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886278/
https://www.ncbi.nlm.nih.gov/pubmed/27241698
http://dx.doi.org/10.1085/jgp.201611581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886278/
https://www.ncbi.nlm.nih.gov/pubmed/27241698
http://dx.doi.org/10.1085/jgp.201611581

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