Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states

The TREK subfamily of two-pore domain (K2P) K(+) channels exhibit polymodal gating by a wide range of physical and chemical stimuli. Crystal structures now exist for these channels in two main states referred to as the “up” and “down” conformations. However, recent studies have resulted in contradic...

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Detalles Bibliográficos
Autores principales: McClenaghan, Conor, Schewe, Marcus, Aryal, Prafulla, Carpenter, Elisabeth P., Baukrowitz, Thomas, Tucker, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886281/
https://www.ncbi.nlm.nih.gov/pubmed/27241700
http://dx.doi.org/10.1085/jgp.201611601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886281/
https://www.ncbi.nlm.nih.gov/pubmed/27241700
http://dx.doi.org/10.1085/jgp.201611601

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