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Interferon-driven alterations of the host’s amino acid metabolism in the pathogenesis of typhoid fever

Enteric fever, caused by Salmonella enterica serovar Typhi, is an important public health problem in resource-limited settings and, despite decades of research, human responses to the infection are poorly understood. In 41 healthy adults experimentally infected with wild-type S. Typhi, we detected s...

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Detalles Bibliográficos
Autores principales: Blohmke, Christoph J., Darton, Thomas C., Jones, Claire, Suarez, Nicolas M., Waddington, Claire S., Angus, Brian, Zhou, Liqing, Hill, Jennifer, Clare, Simon, Kane, Leanne, Mukhopadhyay, Subhankar, Schreiber, Fernanda, Duque-Correa, Maria A., Wright, James C., Roumeliotis, Theodoros I., Yu, Lu, Choudhary, Jyoti S., Mejias, Asuncion, Ramilo, Octavio, Shanyinde, Milensu, Sztein, Marcelo B., Kingsley, Robert A., Lockhart, Stephen, Levine, Myron M., Lynn, David J., Dougan, Gordon, Pollard, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886356/
https://www.ncbi.nlm.nih.gov/pubmed/27217537
http://dx.doi.org/10.1084/jem.20151025