Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses

Antibody affinity maturation occurs in germinal centers (GCs) through iterative rounds of somatic hypermutation and selection. Selection involves B cells competing for T cell help based on the amount of antigen they capture and present on their MHC class II (MHCII) proteins. How GC B cells are able...

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Detalles Bibliográficos
Autores principales: Bannard, Oliver, McGowan, Simon J., Ersching, Jonatan, Ishido, Satoshi, Victora, Gabriel D., Shin, Jeoung-Sook, Cyster, Jason G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886361/
https://www.ncbi.nlm.nih.gov/pubmed/27162138
http://dx.doi.org/10.1084/jem.20151682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886361/
https://www.ncbi.nlm.nih.gov/pubmed/27162138
http://dx.doi.org/10.1084/jem.20151682

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