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Ubiquitin-mediated fluctuations in MHC class II facilitate efficient germinal center B cell responses

Antibody affinity maturation occurs in germinal centers (GCs) through iterative rounds of somatic hypermutation and selection. Selection involves B cells competing for T cell help based on the amount of antigen they capture and present on their MHC class II (MHCII) proteins. How GC B cells are able...

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Detalles Bibliográficos
Autores principales:	Bannard, Oliver, McGowan, Simon J., Ersching, Jonatan, Ishido, Satoshi, Victora, Gabriel D., Shin, Jeoung-Sook, Cyster, Jason G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886361/ https://www.ncbi.nlm.nih.gov/pubmed/27162138 http://dx.doi.org/10.1084/jem.20151682

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