Cargando…
Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites
Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T cell and B cell receptor transgenic mice. We foun...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886365/ https://www.ncbi.nlm.nih.gov/pubmed/27139492 http://dx.doi.org/10.1084/jem.20151869 |