Epstein-Barr virus nuclear protein EBNA3C directly induces expression of AID and somatic mutations in B cells

Activation-induced cytidine deaminase (AID), the enzyme responsible for induction of sequence variation in immunoglobulins (Igs) during the process of somatic hypermutation (SHM) and also Ig class switching, can have a potent mutator phenotype in the development of lymphoma. Using various Epstein-Ba...

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Detalles Bibliográficos
Autores principales: Kalchschmidt, Jens S., Bashford-Rogers, Rachael, Paschos, Kostas, Gillman, Adam C.T., Styles, Christine T., Kellam, Paul, Allday, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886369/
https://www.ncbi.nlm.nih.gov/pubmed/27217538
http://dx.doi.org/10.1084/jem.20160120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886369/
https://www.ncbi.nlm.nih.gov/pubmed/27217538
http://dx.doi.org/10.1084/jem.20160120

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