Smoothened Agonist Reduces Human Immunodeficiency Virus Type-1-Induced Blood-Brain Barrier Breakdown in Humanized Mice

Human Immunodeficiency Virus type-1 (HIV)-associated neurocognitive disorder is characterized by recruitment of activated/infected leukocytes into the CNS via disrupted Blood Brain Barrier (BBB) that contributes to persistent neuro-inflammation. In this report, humanized NOD/scid-IL2Rγ(c)(null) mice...

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Detalles Bibliográficos
Autores principales: Singh, Vir B., Singh, Meera V., Gorantla, Santhi, Poluektova, Larisa Y., Maggirwar, Sanjay B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886511/
https://www.ncbi.nlm.nih.gov/pubmed/27241024
http://dx.doi.org/10.1038/srep26876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886511/
https://www.ncbi.nlm.nih.gov/pubmed/27241024
http://dx.doi.org/10.1038/srep26876

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