Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway

Until now, there is not yet antitumor drug with dramatically improved efficacy on non-small cell lung cancer (NSCLC). Marine organisms are rich source of novel compounds with various activities. We isolated stellettin B (Stel B) from marine sponge Jaspis stellifera, and demonstrated that it induced...

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Detalles Bibliográficos
Autores principales: Wang, Ran, Zhang, Qian, Peng, Xin, Zhou, Chang, Zhong, Yuxu, Chen, Xi, Qiu, Yuling, Jin, Meihua, Gong, Min, Kong, Dexin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886687/
https://www.ncbi.nlm.nih.gov/pubmed/27243769
http://dx.doi.org/10.1038/srep27071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886687/
https://www.ncbi.nlm.nih.gov/pubmed/27243769
http://dx.doi.org/10.1038/srep27071

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