Use of an Improved Matching Algorithm to Select Scaffolds for Enzyme Design Based on a Complex Active Site Model

Active site preorganization helps native enzymes electrostatically stabilize the transition state better than the ground state for their primary substrates and achieve significant rate enhancement. In this report, we hypothesize that a complex active site model for active site preorganization modeli...

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Detalles Bibliográficos
Autores principales: Huang, Xiaoqiang, Xue, Jing, Lin, Min, Zhu, Yushan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887040/
https://www.ncbi.nlm.nih.gov/pubmed/27243223
http://dx.doi.org/10.1371/journal.pone.0156559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887040/
https://www.ncbi.nlm.nih.gov/pubmed/27243223
http://dx.doi.org/10.1371/journal.pone.0156559

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