Investigating the Role of Loop C Hydrophilic Residue ‘T244’ in the Binding Site of ρ1 GABA(C) Receptors via Site Mutation and Partial Agonism

The loop C hydrophilic residue, threonine 244 lines the orthosteric binding site of ρ1 GABA(C) receptors was studied by point mutation into serine, alanine and cysteine, and tested with GABA, some representative partial agonists and antagonists. Thr244 has a hydroxyl group essential for GABA activit...

Descripción completa

Detalles Bibliográficos
Autores principales: Naffaa, Moawiah M., Absalom, Nathan, Solomon, V. Raja, Chebib, Mary, Hibbs, David E., Hanrahan, Jane R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887073/
https://www.ncbi.nlm.nih.gov/pubmed/27244450
http://dx.doi.org/10.1371/journal.pone.0156618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887073/
https://www.ncbi.nlm.nih.gov/pubmed/27244450
http://dx.doi.org/10.1371/journal.pone.0156618

Ejemplares similares