CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease

IFN-γ–producing CD4 T cells are required for protection against Mycobacterium tuberculosis (Mtb) infection, but the extent to which IFN-γ contributes to overall CD4 T cell-mediated protection remains unclear. Furthermore, it is not known if increasing IFN-γ production by CD4 T cells is desirable in...

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Detalles Bibliográficos
Autores principales: Sakai, Shunsuke, Kauffman, Keith D., Sallin, Michelle A., Sharpe, Arlene H., Young, Howard A., Ganusov, Vitaly V., Barber, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887085/
https://www.ncbi.nlm.nih.gov/pubmed/27244558
http://dx.doi.org/10.1371/journal.ppat.1005667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887085/
https://www.ncbi.nlm.nih.gov/pubmed/27244558
http://dx.doi.org/10.1371/journal.ppat.1005667

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