Cargando…

CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease

IFN-γ–producing CD4 T cells are required for protection against Mycobacterium tuberculosis (Mtb) infection, but the extent to which IFN-γ contributes to overall CD4 T cell-mediated protection remains unclear. Furthermore, it is not known if increasing IFN-γ production by CD4 T cells is desirable in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sakai, Shunsuke, Kauffman, Keith D., Sallin, Michelle A., Sharpe, Arlene H., Young, Howard A., Ganusov, Vitaly V., Barber, Daniel L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887085/ https://www.ncbi.nlm.nih.gov/pubmed/27244558 http://dx.doi.org/10.1371/journal.ppat.1005667

Ejemplares similares

CD30 co-stimulation drives differentiation of protective T cells during Mycobacterium tuberculosis infection
por: Foreman, Taylor W., et al.
Publicado: (2023)

Defective positioning in granulomas but not lung-homing limits CD4 T cell interactions with Mycobacterium tuberculosis infected macrophages in rhesus macaques
por: Kauffman, Keith D., et al.
Publicado: (2017)

IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure
por: Lu, Lenette L., et al.
Publicado: (2019)

MAIT cell-directed therapy of Mycobacterium tuberculosis infection
por: Sakai, Shunsuke, et al.
Publicado: (2020)

Kinetics of HIV-Specific CTL Responses Plays a Minimal Role in Determining HIV Escape Dynamics
por: Yang, Yiding, et al.
Publicado: (2018)

Ubiquilin 1 Promotes IFN-γ-Induced Xenophagy of Mycobacterium tuberculosis
por: Sakowski, Erik T., et al.
Publicado: (2015)

IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils
por: Savarin, Carine, et al.
Publicado: (2012)

Multifactorial Remodeling of the Cancer Immunopeptidome by IFNγ
por: Newey, Alice, et al.
Publicado: (2023)

Publisher Correction: IFN-γ-independent immune markers of Mycobacterium tuberculosis exposure
por: Lu, Lenette L., et al.
Publicado: (2019)

Abrogation of IFN-γ Signaling May not Worsen Sensitivity to PD-1/PD-L1 Blockade
por: Vackova, Julie, et al.
Publicado: (2020)

IFN-γ Induces PD-L1 Expression in Primed Human Basophils
por: Bonam, Srinivasa Reddy, et al.
Publicado: (2022)

IFN-γ transforms the transcriptomic landscape and triggers myeloid cell hyperresponsiveness to cause lethal lung injury
por: Verma, Atul K., et al.
Publicado: (2022)

To Achieve an Earlier IFN-γ Response Is Not Sufficient to Control Mycobacterium tuberculosis Infection in Mice
por: Vilaplana, Cristina, et al.
Publicado: (2014)

Extracellular vesicles from IFN-γ-primed mesenchymal stem cells repress atopic dermatitis in mice
por: Kim, Jimin, et al.
Publicado: (2022)

Role of 4-1BB Receptor in the Control Played by CD8(+) T Cells on IFN-γ Production by Mycobacterium tuberculosis Antigen-Specific CD4(+) T Cells
por: Palma, Carla, et al.
Publicado: (2010)

c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis
por: Vollmuth, Nadine, et al.
Publicado: (2022)

Evaluating contribution of the cellular and humoral immune responses to the control of shedding of Mycobacterium avium spp. paratuberculosis in cattle
por: Ganusov, Vitaly V., et al.
Publicado: (2015)

Obesity-Induced Dysbiosis Exacerbates IFN-γ Production and Pulmonary Inflammation in the Mycobacterium tuberculosis Infection
por: Palma Albornoz, Sandra Patricia, et al.
Publicado: (2021)

IFN-γ-Stimulated Neutrophils Suppress Lymphocyte Proliferation through Expression of PD-L1
por: de Kleijn, Stan, et al.
Publicado: (2013)

Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours
por: Martin, Valentina, et al.
Publicado: (2019)

Quantifying Limits on Replication, Death, and Quiescence of Mycobacterium tuberculosis in Mice
por: McDaniel, Margaret M., et al.
Publicado: (2016)

γ-tubulin is differentially expressed in mitotic and non-mitotic cardiomyocytes in the regenerating zebrafish heart
por: Sallin, Pauline, et al.
Publicado: (2015)

IFN-γ Plays a Unique Role in Protection against Low Virulent Trypanosoma cruzi Strain
por: Rodrigues, Adele A., et al.
Publicado: (2012)

Does IFN-γ play a role on the pathogenesis of non-atopic asthma in Latin America children?
por: Figueiredo, Camila Alexandrina, et al.
Publicado: (2012)

IFNγ-Producing B Cells Play a Regulating Role in Infection-Mediated Inhibition of Allergy
por: Qiao, Sai, et al.
Publicado: (2023)

IFNγ/PD-L1 Signaling Improves the Responsiveness of Anti-PD-1 Therapy in Colorectal Cancer: An in vitro Study
por: Yuan, Wenli, et al.
Publicado: (2021)

PD-1(+) IFN-γ(+) subset of CD8(+) T cell in circulation predicts response to anti–PD-1 therapy in NSCLC
por: Chen, Wenxiu, et al.
Publicado: (2023)

Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling
por: Moreira-Teixeira, Lúcia, et al.
Publicado: (2016)

Blockade Effects of Anti-Interferon- (IFN-) γ Autoantibodies on IFN-γ-Regulated Antimicrobial Immunity
por: Krisnawati, Dyah Ika, et al.
Publicado: (2019)

Elevated serum IFN-γand IFN-γ/IL-6 ratio in Kikuchi-Fujimoto disease
por: He, Tingyan, et al.
Publicado: (2023)

Increase of cells expressing PD‐1 and PD‐L1 and enhancement of IFN‐γ production via PD‐1/PD‐L1 blockade in bovine mycoplasmosis
por: Goto, Shinya, et al.
Publicado: (2017)

The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy
por: Qian, Jiawen, et al.
Publicado: (2018)

IFNα and IFNγ Impede Marek’s Disease Progression
por: Bertzbach, Luca D., et al.
Publicado: (2019)

Repression of SPI2 transcription by nitric oxide-producing, IFNγ-activated macrophages promotes maturation of Salmonella phagosomes
por: McCollister, Bruce D., et al.
Publicado: (2005)

Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells
por: Hosokawa, Hiroyuki, et al.
Publicado: (2016)

Different Patterns of Cytokines and Chemokines Combined with IFN-γ Production Reflect Mycobacterium tuberculosis Infection and Disease
por: Yu, Yang, et al.
Publicado: (2012)

IFNγ Response to Mycobacterium tuberculosis, Risk of Infection and Disease in Household Contacts of Tuberculosis Patients in Colombia
por: del Corral, Helena, et al.
Publicado: (2009)

Mycobacterium tuberculosis-Specific IL-21(+)IFN-γ(+)CD4(+) T Cells Are Regulated by IL-12
por: Li, Li, et al.
Publicado: (2016)

Kinetics of Granuloma, IFN-γ and IP-10 in a Wistar Rat Model Infected with Mycobacterium Tuberculosis
por: Singh, Bobby, et al.
Publicado: (2022)

IFN-γ independent markers of Mycobacterium tuberculosis exposure among male South African gold miners
por: Davies, Leela R.L., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_e3h2mnufmcs95h3uroa5fctplg