An ancient yet flexible cis-regulatory architecture allows localized Hedgehog tuning by patched/Ptch1

The Hedgehog signaling pathway is part of the ancient developmental-evolutionary animal toolkit. Frequently co-opted to pattern new structures, the pathway is conserved among eumetazoans yet flexible and pleiotropic in its effects. The Hedgehog receptor, Patched, is transcriptionally activated by He...

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Detalles Bibliográficos
Autores principales: Lorberbaum, David S, Ramos, Andrea I, Peterson, Kevin A, Carpenter, Brandon S, Parker, David S, De, Sandip, Hillers, Lauren E, Blake, Victoria M, Nishi, Yuichi, McFarlane, Matthew R, Chiang, Ason CY, Kassis, Judith A, Allen, Benjamin L, McMahon, Andrew P, Barolo, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887206/
https://www.ncbi.nlm.nih.gov/pubmed/27146892
http://dx.doi.org/10.7554/eLife.13550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887206/
https://www.ncbi.nlm.nih.gov/pubmed/27146892
http://dx.doi.org/10.7554/eLife.13550

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