Monovar: single nucleotide variant detection in single cells

Current variant callers are not suitable for single-cell DNA sequencing (SCS) as they do not account for allelic dropout, false-positive errors, and coverage non-uniformity. We developed Monovar, a novel statistical method for detecting and genotyping single nucleotide variants in SCS data. Evaluati...

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Detalles Bibliográficos
Autores principales: Zafar, Hamim, Wang, Yong, Nakhleh, Luay, Navin, Nicholas, Chen, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887298/
https://www.ncbi.nlm.nih.gov/pubmed/27088313
http://dx.doi.org/10.1038/nmeth.3835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887298/
https://www.ncbi.nlm.nih.gov/pubmed/27088313
http://dx.doi.org/10.1038/nmeth.3835

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