Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs

Drug sensitivity and resistance are conventionally quantified by IC(50) or E(max) values, but these metrics are highly sensitive to the number of divisions taking place over the course of a response assay. The dependency of IC(50) and E(max) on division rate creates artefactual correlations between...

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Detalles Bibliográficos
Autores principales: Hafner, Marc, Niepel, Mario, Chung, Mirra, Sorger, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887336/
https://www.ncbi.nlm.nih.gov/pubmed/27135972
http://dx.doi.org/10.1038/nmeth.3853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887336/
https://www.ncbi.nlm.nih.gov/pubmed/27135972
http://dx.doi.org/10.1038/nmeth.3853

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