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Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs
Drug sensitivity and resistance are conventionally quantified by IC(50) or E(max) values, but these metrics are highly sensitive to the number of divisions taking place over the course of a response assay. The dependency of IC(50) and E(max) on division rate creates artefactual correlations between...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887336/ https://www.ncbi.nlm.nih.gov/pubmed/27135972 http://dx.doi.org/10.1038/nmeth.3853 |