An unbiased metric of antiproliferative drug effect in vitro

In vitro cell proliferation assays are widely used in pharmacology, molecular biology, and drug discovery. Using theoretical modeling and experimentation, we show that current antiproliferative drug effect metrics suffer from time-dependent bias, leading to inaccurate assessments of parameters such...

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Detalles Bibliográficos
Autores principales: Harris, Leonard A., Frick, Peter L., Garbett, Shawn P., Hardeman, Keisha N., Paudel, B. Bishal, Lopez, Carlos F., Quaranta, Vito, Tyson, Darren R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887341/
https://www.ncbi.nlm.nih.gov/pubmed/27135974
http://dx.doi.org/10.1038/nmeth.3852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887341/
https://www.ncbi.nlm.nih.gov/pubmed/27135974
http://dx.doi.org/10.1038/nmeth.3852

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