Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer’s disease

Pathological features in Alzheimer’s brains include mitochondrial dysfunction and dystrophic neurites (DNs) in areas surrounding amyloid plaques. Using a mouse model that overexpresses reticulon 3 (RTN3) and spontaneously develops age-dependent hippocampal DNs, here we report that DNs contain both R...

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Detalles Bibliográficos
Autores principales: Sharoar, Md. Golam, Shi, Qi, Ge, Yingying, He, Wanxia, Hu, Xiangyou, Perry, George, Zhu, Xiongwei, Yan, Riqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887420/
https://www.ncbi.nlm.nih.gov/pubmed/26619807
http://dx.doi.org/10.1038/mp.2015.181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887420/
https://www.ncbi.nlm.nih.gov/pubmed/26619807
http://dx.doi.org/10.1038/mp.2015.181

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