Quinazoline derivative compound (11d) as a novel angiogenesis inhibitor inhibiting VEGFR2 and blocking VEGFR2-mediated Akt/mTOR /p70s6k signaling pathway

OBJECTIVE(S): We previously reported a series of quinazoline derivatives as vascular-targeting anticancer agents. In this study, we investigated the mechanism underlying the anti-angiogenic activity of the quinazoline derivative compound 11d. MATERIALS AND METHODS: We examined the effects of quinazo...

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Detalles Bibliográficos
Autores principales: Li, Zeng, Wang, Bin, Tang, Liang, Chen, Shuangsheng, Li, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887714/
https://www.ncbi.nlm.nih.gov/pubmed/27279985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887714/
https://www.ncbi.nlm.nih.gov/pubmed/27279985

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