Prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large B‐cell lymphoma: a systematic review and meta‐analysis
Published evidence on the prognostic significance of lymphocyte‐to‐monocyte ratio (LMR) in diffuse large B‐cell lymphoma (DLBCL) is controversial. We performed an updated meta‐analysis from 12 reports with 5021 patients to more accurately evaluate the prognostic value of LMR in DLBCL. Herein, we con...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887971/ https://www.ncbi.nlm.nih.gov/pubmed/27419058 http://dx.doi.org/10.1002/2211-5463.12066 |
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author | Xia, Wen‐Kai Lin, Qing‐Feng Shen, Dong Liu, Zhi‐Li Su, Jun Mao, Wei‐Dong |
author_facet | Xia, Wen‐Kai Lin, Qing‐Feng Shen, Dong Liu, Zhi‐Li Su, Jun Mao, Wei‐Dong |
author_sort | Xia, Wen‐Kai |
collection | PubMed |
description | Published evidence on the prognostic significance of lymphocyte‐to‐monocyte ratio (LMR) in diffuse large B‐cell lymphoma (DLBCL) is controversial. We performed an updated meta‐analysis from 12 reports with 5021 patients to more accurately evaluate the prognostic value of LMR in DLBCL. Herein, we confirmed that patients with low LMR had shorter overall survival and progression‐free survival than those with high LMR in DLBCL. Subgroup analyses indicated that patient source, cut‐off values of LMR, treatment methods, and sample size showed similar prognostic performance in DLBCL patients. No significant heterogeneity was observed for progression‐free survival (PFS, P (het) = 0.192) among the enrolled studies. The meta‐analysis suggests that the LMR may be a potential biomarker in the prediction of clinical outcomes for DLBCL patients. |
format | Online Article Text |
id | pubmed-4887971 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-48879712016-07-14 Prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large B‐cell lymphoma: a systematic review and meta‐analysis Xia, Wen‐Kai Lin, Qing‐Feng Shen, Dong Liu, Zhi‐Li Su, Jun Mao, Wei‐Dong FEBS Open Bio Research Articles Published evidence on the prognostic significance of lymphocyte‐to‐monocyte ratio (LMR) in diffuse large B‐cell lymphoma (DLBCL) is controversial. We performed an updated meta‐analysis from 12 reports with 5021 patients to more accurately evaluate the prognostic value of LMR in DLBCL. Herein, we confirmed that patients with low LMR had shorter overall survival and progression‐free survival than those with high LMR in DLBCL. Subgroup analyses indicated that patient source, cut‐off values of LMR, treatment methods, and sample size showed similar prognostic performance in DLBCL patients. No significant heterogeneity was observed for progression‐free survival (PFS, P (het) = 0.192) among the enrolled studies. The meta‐analysis suggests that the LMR may be a potential biomarker in the prediction of clinical outcomes for DLBCL patients. John Wiley and Sons Inc. 2016-05-04 /pmc/articles/PMC4887971/ /pubmed/27419058 http://dx.doi.org/10.1002/2211-5463.12066 Text en © 2016 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Xia, Wen‐Kai Lin, Qing‐Feng Shen, Dong Liu, Zhi‐Li Su, Jun Mao, Wei‐Dong Prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large B‐cell lymphoma: a systematic review and meta‐analysis |
title | Prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large B‐cell lymphoma: a systematic review and meta‐analysis |
title_full | Prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large B‐cell lymphoma: a systematic review and meta‐analysis |
title_fullStr | Prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large B‐cell lymphoma: a systematic review and meta‐analysis |
title_full_unstemmed | Prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large B‐cell lymphoma: a systematic review and meta‐analysis |
title_short | Prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large B‐cell lymphoma: a systematic review and meta‐analysis |
title_sort | prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large b‐cell lymphoma: a systematic review and meta‐analysis |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887971/ https://www.ncbi.nlm.nih.gov/pubmed/27419058 http://dx.doi.org/10.1002/2211-5463.12066 |
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