Prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large B‐cell lymphoma: a systematic review and meta‐analysis

Published evidence on the prognostic significance of lymphocyte‐to‐monocyte ratio (LMR) in diffuse large B‐cell lymphoma (DLBCL) is controversial. We performed an updated meta‐analysis from 12 reports with 5021 patients to more accurately evaluate the prognostic value of LMR in DLBCL. Herein, we con...

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Autores principales: Xia, Wen‐Kai, Lin, Qing‐Feng, Shen, Dong, Liu, Zhi‐Li, Su, Jun, Mao, Wei‐Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887971/
https://www.ncbi.nlm.nih.gov/pubmed/27419058
http://dx.doi.org/10.1002/2211-5463.12066
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author Xia, Wen‐Kai
Lin, Qing‐Feng
Shen, Dong
Liu, Zhi‐Li
Su, Jun
Mao, Wei‐Dong
author_facet Xia, Wen‐Kai
Lin, Qing‐Feng
Shen, Dong
Liu, Zhi‐Li
Su, Jun
Mao, Wei‐Dong
author_sort Xia, Wen‐Kai
collection PubMed
description Published evidence on the prognostic significance of lymphocyte‐to‐monocyte ratio (LMR) in diffuse large B‐cell lymphoma (DLBCL) is controversial. We performed an updated meta‐analysis from 12 reports with 5021 patients to more accurately evaluate the prognostic value of LMR in DLBCL. Herein, we confirmed that patients with low LMR had shorter overall survival and progression‐free survival than those with high LMR in DLBCL. Subgroup analyses indicated that patient source, cut‐off values of LMR, treatment methods, and sample size showed similar prognostic performance in DLBCL patients. No significant heterogeneity was observed for progression‐free survival (PFS, P (het) = 0.192) among the enrolled studies. The meta‐analysis suggests that the LMR may be a potential biomarker in the prediction of clinical outcomes for DLBCL patients.
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spelling pubmed-48879712016-07-14 Prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large B‐cell lymphoma: a systematic review and meta‐analysis Xia, Wen‐Kai Lin, Qing‐Feng Shen, Dong Liu, Zhi‐Li Su, Jun Mao, Wei‐Dong FEBS Open Bio Research Articles Published evidence on the prognostic significance of lymphocyte‐to‐monocyte ratio (LMR) in diffuse large B‐cell lymphoma (DLBCL) is controversial. We performed an updated meta‐analysis from 12 reports with 5021 patients to more accurately evaluate the prognostic value of LMR in DLBCL. Herein, we confirmed that patients with low LMR had shorter overall survival and progression‐free survival than those with high LMR in DLBCL. Subgroup analyses indicated that patient source, cut‐off values of LMR, treatment methods, and sample size showed similar prognostic performance in DLBCL patients. No significant heterogeneity was observed for progression‐free survival (PFS, P (het) = 0.192) among the enrolled studies. The meta‐analysis suggests that the LMR may be a potential biomarker in the prediction of clinical outcomes for DLBCL patients. John Wiley and Sons Inc. 2016-05-04 /pmc/articles/PMC4887971/ /pubmed/27419058 http://dx.doi.org/10.1002/2211-5463.12066 Text en © 2016 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Xia, Wen‐Kai
Lin, Qing‐Feng
Shen, Dong
Liu, Zhi‐Li
Su, Jun
Mao, Wei‐Dong
Prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large B‐cell lymphoma: a systematic review and meta‐analysis
title Prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large B‐cell lymphoma: a systematic review and meta‐analysis
title_full Prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large B‐cell lymphoma: a systematic review and meta‐analysis
title_fullStr Prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large B‐cell lymphoma: a systematic review and meta‐analysis
title_full_unstemmed Prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large B‐cell lymphoma: a systematic review and meta‐analysis
title_short Prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large B‐cell lymphoma: a systematic review and meta‐analysis
title_sort prognostic significance of lymphocyte‐to‐monocyte ratio in diffuse large b‐cell lymphoma: a systematic review and meta‐analysis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887971/
https://www.ncbi.nlm.nih.gov/pubmed/27419058
http://dx.doi.org/10.1002/2211-5463.12066
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