Light-induced nuclear export reveals rapid dynamics of epigenetic modifications

We engineered a photoactivatable system for rapidly and reversibly exporting proteins from the nucleus by embedding a nuclear export signal in the LOV2 domain from phototropin 1. Fusing the chromatin modifier Bre1 to the photoswitch, we achieved light-dependent control of histone H2B monoubiquitylat...

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Detalles Bibliográficos
Autores principales: Yumerefendi, Hayretin, Lerner, Andrew Michael, Zimmerman, Seth Parker, Hahn, Klaus, Bear, James E, Strahl, Brian D., Kuhlman, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888063/
https://www.ncbi.nlm.nih.gov/pubmed/27089030
http://dx.doi.org/10.1038/nchembio.2068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888063/
https://www.ncbi.nlm.nih.gov/pubmed/27089030
http://dx.doi.org/10.1038/nchembio.2068

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