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Light-induced nuclear export reveals rapid dynamics of epigenetic modifications
We engineered a photoactivatable system for rapidly and reversibly exporting proteins from the nucleus by embedding a nuclear export signal in the LOV2 domain from phototropin 1. Fusing the chromatin modifier Bre1 to the photoswitch, we achieved light-dependent control of histone H2B monoubiquitylat...
Autores principales: | Yumerefendi, Hayretin, Lerner, Andrew Michael, Zimmerman, Seth Parker, Hahn, Klaus, Bear, James E, Strahl, Brian D., Kuhlman, Brian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888063/ https://www.ncbi.nlm.nih.gov/pubmed/27089030 http://dx.doi.org/10.1038/nchembio.2068 |
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