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ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in mice

Cannabidiol (CBD) is currently being investigated as a novel therapeutic for the treatment of CNS disorders like schizophrenia and epilepsy. ABC transporters such as P-glycoprotein (P-gp) and breast cancer resistance protein (Bcrp) mediate pharmacoresistance in these disorders. P-gp and Bcrp are exp...

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Detalles Bibliográficos
Autores principales:	Brzozowska, Natalia, Li, Kong M., Wang, Xiao Suo, Booth, Jessica, Stuart, Jordyn, McGregor, Iain S., Arnold, Jonathon C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2016
Materias:	Drugs and Devices
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888295/ https://www.ncbi.nlm.nih.gov/pubmed/27257556 http://dx.doi.org/10.7717/peerj.2081

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